“I’m so hot,” the 48-year-old actress said while taking off her blazer and fanning herself. “I think I’m having one of my first perimenopause hot flashes.”

Barrymore joked that “maybe” she was just “that excited” to be interviewing Jennifer Aniston and Adam Sandler on “The Drew Barrymore Show.”

“Oh, I’m so honored!” the “Friends” star, 54, said of witnessing the milestone.

As for Sandler, the actor, 56, reached out toward Barrymore and commented on his “50 First Dates” co-star’s “hot hand.”

“That’s good ’cause if it was good, that would be worrisome,” the host responded. “Well, I’m so glad I have this moment documented!”

After Barrymore posted the clip via Instagram, fans praised her for keeping it real.

“This is so important … to share,” one social media user wrote. “How beautiful!”

Another gushed, “Thank you for helping to normalize talking openly about perimenopause and menopause! 🔥🔥.”

Last week, the “Scream” star spoke to Gayle King about her menopause journey during a “CBS This Morning” interview.

“I realized that I was in perimenopause when I started having my period every two weeks,” she explained.

“One doctor also just told me this could last, in the worst case scenario, 10 years,” the “Charlie’s Angels” star continued. “And I was like, ‘I will never make it 10 years like this!’”